Runtime.PythonDLL = @"/usr/lib/x86_64-linux-gnu/libpython3.12.so";

string pathToVirtualEnv = @"/home/jadan/venvs/venv_mare";

string path = Environment.GetEnvironmentVariable("PATH")!.TrimEnd(Path.PathSeparator);
path = string.IsNullOrEmpty(path) ? pathToVirtualEnv : path + Path.PathSeparator + pathToVirtualEnv;
Environment.SetEnvironmentVariable("PATH", path, EnvironmentVariableTarget.Process);
Environment.SetEnvironmentVariable("PYTHONHOME", pathToVirtualEnv, EnvironmentVariableTarget.Process);
Environment.SetEnvironmentVariable("PYTHONPATH",
     $"{pathToVirtualEnv}/lib/site-packages{Path.PathSeparator}" + 
     $"{pathToVirtualEnv}{Path.PathSeparator}", EnvironmentVariableTarget.Process);

PythonEngine.PythonPath = PythonEngine.PythonPath + Path.PathSeparator + Environment.GetEnvironmentVariable("PYTHONPATH", EnvironmentVariableTarget.Process);
PythonEngine.PythonHome = pathToVirtualEnv;

PythonEngine.Initialize();

using (Py.GIL())
{
     dynamic np = Py.Import("numpy");
}

Python path configuration:
  PYTHONHOME = '/home/jadan/venvs/venv_mare'
  PYTHONPATH = (not set)
  program name = 'python3'
  isolated = 0
  environment = 1
  user site = 1
  safe_path = 0
  import site = 1
  is in build tree = 0
  stdlib dir = ''
  sys._base_executable = '/usr/bin/python3'
  sys.base_prefix = ''
  sys.base_exec_prefix = ''
  sys.platlibdir = 'lib'
  sys.executable = '/usr/bin/python3'
  sys.prefix = ''
  sys.exec_prefix = ''
  sys.path = [
    '',
    '/home/jadan/venvs/venv_mare/lib/python3.12/site-packages',
    '/home/jadan/venvs/venv_mare',
    '',
  ]
Fatal Python error: init_fs_encoding: failed to get the Python codec of the filesystem encoding
Python runtime state: core initialized
ModuleNotFoundError: No module named 'encodings'