Abstract
Introduction
Apart from impacting motor functioning, Parkinson’s disease (PD) also impacts emotional and social aspects of life. Psychosocial difficulties can influence independence, relationships, and overall quality of life. Gender roles and expectations may shape how these problems are experienced.
Objectives
This study aimed to evaluate gender-related differences in psychosocial functioning among patients with PD using the Scales for Outcomes in Parkinson’s Disease–Psychosocial Functioning (SCOPA-PS).
Methods
Data was analysed for patients with PD who were prospectively recruited between July 2022-September 2025 as part of the Young and Late Onset Parkinson’s Disease (YLOPD) study, funded by the SKAN Research Trust, at the National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. Psychosocial functioning was assessed using the SCOPA-PS.
Results
The study included 484 patients (330 men, 154 women). Men and women were comparable in age, age at onset and duration of illness. Women had slightly higher OFF state scores. SCOPA-PS total scores were significantly higher in women. Women reported significantly greater difficulty with household chores, leisure activities, interpersonal relationships, feeling house-bound, dependence on others, and loneliness.
Conclusion
Women with PD exhibited significantly higher psychosocial burden compared to men. These differences likely reflect the influence of gender-related social roles, expectations, and perceived dependence. Altered psychosocial functioning in PD can significantly affect self-esteem, relationships, and adaptation to illness. Addressing these gender-specific challenges through tailored psychosocial support can improve engagement, emotional well-being, and overall quality of life in people living with PD.
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Data availability
The datasets generated and/or analyzed during the current study are not publicly available due to ethical and privacy considerations but are available from the corresponding author on reasonable request.
References
Abraham A, Bay AA, Ni L, Schindler N, Singh E, Leeth E et al (2023) Gender differences in motor and non-motor symptoms in individuals with mild-moderate parkinson’s disease. PLoS ONE 18(1):e0272952
Bianchi SM, Sayer LC, Milkie MA, Robinson JP, Housework (2012) Who did, does or will do it, and how much does it matter? Soc Forces 91(1):55–63
Bloem BR, Henderson EJ, Dorsey ER, Okun MS, Okubadejo N, Chan P et al (2020) Integrated and patient-centred management of parkinson’s disease: a network model for reshaping chronic neurological care. Lancet Neurol 19(7):623–634
Calne SM, Lidstone SC, Kumar A (2008) Psychosocial issues in young-onset parkinson’s disease: current research and challenges. Parkinsonism Relat Disord 14(2):143–150
Craig L, Mullan K (2010) Parenthood, gender and work-family time in the united States, Australia, Italy, France, and Denmark. J Marriage Family 72(5):1344–1361
Crispino P, Gino M, Barbagelata E, Ciarambino T, Politi C, Ambrosino I et al (2021) Gender differences and quality of life in parkinson’s disease. Int J Environ Res Public Health 18(1):198
Crooks S, Mitchell G, Wynne L, Carter G (2025) Exploring the stigma experienced by people affected by parkinson’s disease: a systematic review. BMC Public Health 25(1):25
Erickson RJ (2005) Why emotion work matters: Sex, gender, and the division of household labor. J Marriage Family 67(2):337–351
Farhadi F, Vosoughi K, Shahidi GA, Delbari A, Lökk J, Fereshtehnejad S-M (2017) Sexual dimorphism in Parkinson’s disease: differences in clinical manifestations, quality of life, and psychosocial functioning between males and females. Neuropsychiatr Dis Treat 13:329–338
Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P et al (2008) Movement disorder Society‐sponsored revision of the unified parkinson’s disease rating scale (MDS‐UPDRS): scale presentation and clinimetric testing results. Mov Disord 23(15):2129–2170
Harris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O’Neal L et al (2019) The REDCap consortium: Building an international community of software platform partners. J Biomed Inform 95:103208
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG (2009) Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42(2):377–381
Koerts J, Van Beilen M, Tucha O, Leenders KL, Brouwer WH (2011) Executive functioning in daily life in parkinson’s disease: initiative, planning and multi-task performance. PLoS ONE 6(12):e29254
Kulsum ZA, Sinha A (2023) Gender stereotypes, societal pressure and emotional expression among men. Int J Indian Psychol 11(3):2078–2085
Marcussen K, Ritter C, Safron DJ (2004) The role of identity salience and commitment in the stress process. Sociol Perspect 47(3):289–312
Marinus J, Visser M, Martı́nez-Martı́n P, van Hilten JJ, Stiggelbout AM (2003) A short psychosocial questionnaire for patients with parkinson’s disease: the SCOPA-PS. J Clin Epidemiol 56(1):61–67
Martinez-Martin P, Rodriguez-Blazquez C, Abe K, Bhattacharyya KB, Bloem BR, Carod-Artal FJ et al (2009) International study on the psychometric attributes of the non-motor symptoms scale in Parkinson disease. Neurology 73(19):1584–1591
Martinez-Martin P, Rodriguez-Blazquez C, Kurtis MM, Chaudhuri KR, Group NV (2011) The impact of non-motor symptoms on health-related quality of life of patients with parkinson’s disease. Mov Disord 26(3):399–406
McDaniels B, Subramanian I (2024) Psychosocial challenges associated with Parkinson’s disease. In: Martin CR, Preedy VR, Patel VB, Rajendram R (eds) Handbook of the Behavior and Psychology of Disease. Springer, Cham, pp 1–27
Pont-Sunyer C, Hotter A, Gaig C, Seppi K, Compta Y, Katzenschlager R et al (2015) The onset of nonmotor symptoms in Parkinson’s disease (the ONSET PD study). Mov Disord 30:229–237. https://doi.org/10.1002/mds.26077
Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W et al (2015) MDS clinical diagnostic criteria for parkinson’s disease. Mov Disord 30(12):1591–1601
Prell T, Schönenberg A, Heimrich KG (2023) The impact of loneliness on quality of life in people with parkinson’s disease: results from the survey of Health, ageing and retirement in Europe. Front Med 10:1183289
Reese SL (2007) Psychosocial factors in parkinson’s disease. Dis Mon 53(5):291–295
Robb C, Small B, Haley WE (2008) Gender differences in coping with functional disability in older married couples: the role of personality and social resources. Aging Mental Health 12(4):423–433
Santos-García D, Laguna A, Hernández-Vara J, de Deus Fonticoba T, Cores Bartolomé C, Feal Painceiras MJ et al (2023) Sex differences in motor and non-motor symptoms among Spanish patients with parkinson’s disease. J Clin Med 12(4):1329
Schapira AHV, Chaudhuri KR, Jenner P (2017) Non-motor features of Parkinson disease. Nat Rev Neurosci 18(7):435–450
Singh P, Pattanaik F (2020) Unfolding unpaid domestic work in india: women’s constraints, choices, and career. Palgrave Commun 6(1):1–13
Stella F, Banzato CE, Quagliato EMB, Viana MA (2008) Depression in patients with parkinson’s disease: impact on functioning. J Neurol Sci 272(1–2):158–163
Tareque MI, Tiedt AD, Islam TM, Begum S, Saito Y (2017) Gender differences in functional disability and self-care among seniors in Bangladesh. BMC Geriatr 17(1):177
Virués-Ortega J, Carod-Artal FJ, Serrano-Dueñas M, Ruiz-Galeano G, Meza-Rojas G, Velázquez C et al (2009) Cross-cultural validation of the scales for outcomes in parkinson’s Disease-Psychosocial questionnaire (SCOPA-PS) in four Latin American countries. Value Health 12(2):385–391
Yoon J-E, Kim JS, Jang W, Park J, Oh E, Youn J et al (2017) Gender differences of nonmotor symptoms affecting quality of life in Parkinson disease. Neurodegenerative Dis 17(6):276–280
Zhang T, Yao L, Li T, Tian H, Song G (2024) The levels and associated factors for participation and autonomy among people with Parkinson’s disease: a cross-sectional study. Psychol Res Behav Manag 17:1045–1055
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Scientific Knowledge for Ageing and Neurological ailments (SKAN) research trust.
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SP: Research project: Conception, Organization, Execution; Statistical Analysis: Design, Execution; Manuscript Preparation: Writing of the first draft. MB: Research project: Conception, Organization; Statistical Analysis: Design, Review and Critique; Manuscript Preparation: Review and Critique. TN: Research project: Conception, Organization; Statistical Analysis: Design, Review and Critique; Manuscript Preparation: Review and Critique. SGSB: Research project: Conception, Organization; Statistical Analysis: Design, Review and Critique; Manuscript Preparation: Review and Critique. KJK: Research project: Conception, Organization; Statistical Analysis: Design, Review and Critique; Manuscript Preparation: Review and Critique. PM: Research project: Conception, Statistical Analysis: Review and Critique; Manuscript Preparation: Review and Critique. RMR: Research project: Conception, Organization; Statistical Analysis: Review and Critique; Manuscript Preparation: Review and Critique. VVH: Research project: Conception, Organization; Statistical Analysis: Review and Critique; Manuscript Preparation: Review and Critique. NK: Research project: Conception, Organization; Statistical Analysis: Review and Critique; Manuscript Preparation: Review and Critique. RY: Research project: Conception, Organization; Statistical Analysis: Review and Critique; Manuscript Preparation: Review and Critique. PKP: Research project: Conception, Organization; Statistical Analysis: Design, Review and Critique; Manuscript Preparation: Review and Critique
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Prasad, S., Bhardwaj, M., Nagaraj, T. et al. Differential psychosocial burden in parkinson’s disease: a gender-based comparison. J Neural Transm (2026). https://doi.org/10.1007/s00702-026-03120-4
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DOI: https://doi.org/10.1007/s00702-026-03120-4