Highlights

  • Shaping male behaviours in fish

    Estrogens produced in the brain increase neural sensitivity to testicular androgens, and thus elicit male-typical behaviors, in the Japanese rice fish.

    Yuji Nishiike, Shizuku Maki ... Kataaki Okubo
    Research Article
  • X-rays impact gene expression

    Exposing the wing discs of Drosophila to X-rays leads to heterogenous changes in gene expression that are related to cell-cycle status and cell location.

    Joyner Cruz, Willam Y Sun ... Iswar K Hariharan
    Reviewed Preprint Updated
  • Reprogramming progenitor cells

    Progenitor cells destined to become glial cells can be reprogrammed to become corticospinal-like neurons

    Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
    Research Article
  • Research culture

    The Researcher Development Concordat has led to improvements in research culture in the UK, but there is still more to do.

    Robert AR Drake, Laura A Gray ... Joan Chang
    Feature Article
  • Where theory meets biology

    eLife author Veronika Koren, a computational neuroscientist, answers questions about her work on efficient coding.

    Inside eLife
  • What is a Reviewed Preprint?

    Reviewed Preprints provide benefits to authors and to the wider scientific community.

    Inside eLife

Latest research

    1. Genetics and Genomics
    2. Immunology and Inflammation

    Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B

    Ozkan Aydemir, Jeffrey A Bailey ... TEDDY Study Group
    HLA-DRA intronic haplotype associates with opposite effects on type 1 diabetes and celiac disease, refining genetic risk prediction and implicating complement genes C4A and C4B in divergent autoimmune pathways.
    1. Neuroscience

    Information, certainty, and learning

    Justin A Harris, Charles Randy Gallistel
    The acquisition and expression of Pavlovian conditioned responding are shown to be lawfully related to objectively specifiable temporal properties of the events the animal is learning about.
    1. Developmental Biology

    Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells

    Hiroki Tsutsumi, Tomoki Chiba ... Hiroshi Asahara
    Single-cell profiling reveals CD55+CD248+ tendon stem/progenitor cells.
    1. Neuroscience

    Progressive overfilling of readily releasable pool underlies short-term facilitation at recurrent excitatory synapses in layer 2/3 of the rat prefrontal cortex

    Jiwoo Shin, Seung Yeon Lee ... Suk-Ho Lee
    Revised
    Reviewed Preprint v5
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Ventromedial striatal dopamine dynamically integrates motivated action and reward proximity

    Eugenia Z Poh, Nicky L Buitelaar ... Ingo Willuhn
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Backward Conditioning Reveals Flexibility in Infralimbic Cortex Inhibitory Memories

    Nura W Lingawi, Billy C Chieng ... Vincent Laurent
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    A forebrain hub for cautious actions via the midbrain

    Ji Zhou, Muhammad Sarmad Sajid ... Manuel A Castro-Alamancos
    Cautious action timing under threat depends on glutamatergic signaling from the subthalamic nucleus to the midbrain, revealing a circuit mechanism for adaptive goal-directed behavior.
    1. Computational and Systems Biology

    The representation of facial emotion expands from sensory to prefrontal cortex with development

    Xiaoxu Fan, Abhishek Tripathi, Kelly Bijanki
    Facial emotion representations expand from sensory cortex to prefrontal regions across development, suggesting that the prefrontal cortex matures with development to enable a full understanding of facial emotion.
    1. Neuroscience

    Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision-making

    Miguel Barretto-Garcia, Marcus Grueschow ... Christian C Ruff
    Disrupting left superior frontal sulcus selectively impaired perceptual but not value-based decisions, revealing segregated prefrontal circuits for integrating sensory evidence versus subjective preferences in human choice behaviour.