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A library to analyse the structure of 1d loops and simulate loop extrusion by loop extruding factors.

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GalRoss/looplib

 
 

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Simulate loop extrusion by loop extruding factors and analyse the resulting structures of loops.

  • simlef.pyx - simulate loop extrusion in 1d with simulate()

  • looptools.py - analyse the structure of extruded loops:

    • build trees of nested loops with get_parent_loops()
    • find root loops with get_roots()
    • identify the positions between the root loops with get_backbone()
    • identify stacked LEFs with stack_lefs()
  • loopviz.py - visualize loops with plot_lefs()

  • loopviz_circular.py - visualize loops on the genome with plot_circular_genome_with_loops()

  • looplib_bacterial_gal folder:

    • bacterial_no_bypassing.pyx - Simulate non-bypassing loop extrusion by LEF with simulate()
  • LEF_paths_gen.py - generate LEF paths on the genome several times and save into .h5 files

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A library to analyse the structure of 1d loops and simulate loop extrusion by loop extruding factors.

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  • Cython 53.6%
  • Python 24.7%
  • Julia 21.7%