Abstract
An aging global population requires preventive and curative interventions to address cognitive decline. Touchscreen computerized cognitive training provides an engaging, portable, cost-effective, and accessible solution for seniors. We conducted a systematic review of randomized controlled trials (RCTs) to determine, using meta-analysis, the effects of computerized cognitive training on older adults using touchscreens. We conducted a literature review to identify RCTs involving older adults in touchscreen computerized cognitive training between 2016 and January 2025 on PubMed, Cochrane, ScienceDirect, and Google Scholar. Our research identified 34 studies involving 3,011 participants and, despite methodological variations, some of them assessed cognition using similar tests such as the Mini-Mental State Examination (MMSE), the Digit Span (DS), and the Trail Making Test (TMT) task. Cross-study analysis indicated a significant impact of computerized cognitive training on MMSE, MoCA, GDS, TMT, and DS scores. Computerized cognitive training applied on touchscreens demonstrates a statistically significant effect on overall cognition, short-term memory, working memory, processing speed, attention, and flexibility. Nevertheless, future studies in this area need to be more standardized and more rigorous to demonstrate validating effects and establish an accessible attribution environment.
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Introduction
Background
Global public health in the twenty-first century faces major challenges related to the aging of the population and the expected increase in cases of dementia. According to projections cited by the World Health Organization (WHO), the world’s population aged over 60 is expected to double by 2050 [1, 2]. Aging presents many challenges, one of which is associated with age-related cognitive decline. Memory, as a cognitive process used on a daily basis, becomes an easily recognizable indicator for the detection of cognitive decline. A memory problem reflects impairments in cognitive functions such as attention, processing speed, language or executive functions [4]. Mild Cognitive Impairment (MCI) is common with age and is associated with increased mortality [7].
Cognitive Impairments may arise from various conditions, such as age-related decline in older adults. These impairments may involve deficits in working memory, which is a cognitive system that maintains, processes, and links information between perception, long-term memory, and action [8, 9]. Working memory plays an important role in executing daily living activities successfully. Moreover, executive functions, which encompass a broad set of cognitive processes affecting learning abilities, problem solving, and self-control, contribute to the execution of activities comprising daily life and are important for preserving an individual’s ability to remain independent [10].
Treatments for cognitive decline
Clinical trials have been conducted to delay cognitive decline, including cholinesterase inhibitors such as donepezil and antioxidant compounds such as vitamin E [12,13,14]. Overall, pharmacological trials in mild cognitive impairment have produced limited and inconsistent results, and some treatments may be subject to adverse effects [14, 15]. Currently, there is no specific pharmacological treatment for people with MCI, despite the condition affecting approximately 15–20% of individuals over 65 years old [11]. Non-pharmacological interventions, based on principles of brain plasticity, represent promising approaches for supporting cognitive functions. Brain plasticity reflects the ability to establish new neuronal connections and strengthen existing synaptic links in humans. This ability is maintained with age and seems to play an important role in research on mitigating cognitive decline [16, 17]. Recent research highlights the role of neuronal and cognitive plasticity for the aging brain [16, 19]. The theory of neuroplasticity appears to be an important theoretical framework for research on computerized cognitive training as it helps explain how cognitive stimulation may support adaptive changes in brain function. However, the decline with age is heterogeneous and varies among individuals. Brain plasticity is also subject to variation largely attributable to differences in cognitive reserve which, in turn, is associated with how individuals cope with cognitive decline and brain pathology. Cognitive reserve is defined as “individual differences in how people process tasks allow some to cope better than others with brain pathology” [20]. Factors influencing variation in cognitive reserve include genetics, education, occupation, socioeconomic status, physical health, lifestyle, and mental activity [21]. Individual intervention is therefore necessary in the prevention and treatment of cognitive decline since needs are variable and malliable during each intervention.
Cognitive training intervention
Cognitive training can be defined as “an intervention providing structured practice on tasks relevant to aspects of cognitive functioning, using standardized tasks, and intended to address cognitive function and/or cognitive impairment directly” [22]. Cognitive training has shown effects on working memory, processing speed and visuospatial abilities [23, 24]. However, practical difficulties limit their use, particularly with regard to face-to-face prescription, making the intervention inaccessible to patients with reduced mobility [25]. Furthermore, studies carried out on cognitive training have received criticism concerning the high proportion of results attributable to placebo effects, mainly due to the fact that it is not possible to hide the expectations of the studies. The contextual effect inherent to a training intervention and the self-selection bias of volunteers are mainly highlighted as a factor that limits the conclusions [26, 27].
Advent of computerized cognitive training
Computer technology has created new opportunities to diversify programs by moving towards computerized cognitive training [28]. Simultaneously, the advent of computerized cognitive training has resulted in industrial market growth, with a plethora of cognitive stimulation and training applications with controversial levels of evidence [29,30,31]. Nevertheless, extant research findings are in agreement regarding the modest to moderate effects of initial computerized cognitive training programs on both overall cognition, but also on more specific functions, such as executive functions, processing speed, attention and memory [11, 18, 32, 33]. Analyses suggest that computer programs may lead to improvements in symptoms of neuropsychiatric disorders, including anxiety and depression [34, 35]. Computer-based training presents new opportunities, leveraging the benefits of e-Health, such as cost savings for healthcare facilities, solutions for areas with limited medical access, and reduced intervention costs. Those technologies enable both accessible and inclusive sessions. This is achieved through the provision of at-home sessions for individuals with reduced mobility, and the incorporation of common technologies, such as tablets and smartphones [36]. Many studies have focused on engagement and motivation in computerized cognitive training for seniors during computerized programs [18, 30]. Counter-intuitively, cognitive training does not appear to require prior computer experience [37]. Digital environments provide a larger range of activities with adjustable levels of complexity, enabling the opportunity to engage in specific training targeting particular cognitive processes such as inhibition and visual attention [38,39,40]. Real-time feedback and adjustments have the capacity to enhance patient engagement and individualize remediation. Nevertheless, the effectiveness of computerized cognitive training remains a subject of controversy, particularly with regard to the magnitude of the effects and the transfer effects [41, 42]. Skepticism towards computerized cognitive remediation has been partly driven by the lack of standardization of studies, which complicates the analysis of results. In addition, variability in intervention protocols and an absence of randomized controlled trials did not provide the opportunity to draw conclusions on their effectiveness [39]. Methodological disparities in computerized cognitive program research are influenced by the potential protocol effects on the results, heterogeneity of the study population, variability of specific cognitive functions targeted, and a presumed paucity of rigorous control over socio-demographic and genetics factors [35, 43,44,45,46,47].
However, recent work has provided crucial knowledge for more standardized studies. Long-term compliance, short but frequent sessions, and favorable conditions can influence observed outcomes in computerized training [48, 49]. Gamification, defined by the use of game elements in contexts other than entertainment, is a contributing factor to adherence to programs necessitating long-term intervention [50, 51]. Playful interfaces appear to increase the attractiveness of the exercises offered in bright environments and simple interaction, maintaining patients’ motivation for the environments offered [18]. Some studies have highlighted the main factors of disengagement. The primary one comprises of the difficulty in integrating traditional activities into daily life. The second one pertains to the lack of diversity in the exercises offered [52]. To respond to these limitations and reach the public in an enhanced preventive approach, aiming to maintain cognitive faculties, a global approach to programs on smartphones and tablets appears appropriate. In addition, touchscreen technology meliorates accessibility to home programs for patients not only by maintaining communication with therapists, but also by integrating several activities into their daily routines [18]. Touchscreens are generally considered easier to use than other human-machine interface aids such as keyboards and mouse. These engaging results for tactile interfaces should be considered as they vary depending on the population studied. For seniors prone to Parkinson’s disease, in particular, studies involving fine movements on touchscreens should be avoided. Despite the computers’ predominance in computerized cognitive training studies, the trend could be reversed in the future by the increased use of tactile devices [18, 52, 54, 55]. Indeed, touchscreens appear to compensate for the limitations of other interfaces and provide a more accessible therapeutic medium for the elderly [3]. It is hypothesized that a focus on enhancing accessibility through touchscreens and gamified content can mitigate many of the challenges associated with cognitive training for older adults. Gamified exercise refers to activities that incorporate game design concepts such as user feedback or reward systems into their design.
Aims and objectives
The aim of this study is to analyze the latest advances on effectiveness of computerized cognitive training using touchscreen devices. To our knowledge, although several studies have been carried out on computerized cognitive programs [38, 56, 57], none have validated the results of RCTs on programs for the elderly specifically distributed on touchscreens. As such, no systematic review was found in the PROSPERO database. However, it is hypothesized that the attribution interface plays a major role in program outcomes in addition to facilitating standardized practices. This study was conducted with the aim to better understand the factors contributing to the divergent outcomes associated with computerized cognitive programs. It focuses on a form of program administration that assumes an improvement in results through standardization of protocols and an improvement in the accessibility of interventions for seniors.
Methods
Procedure
To assess the effects of cognitive training delivered via touchscreens, a systematic review was conducted during early 2025, and early online publications available within this interval were included. This review was conducted following the main principles of the PRISMA 2020 guidelines, including a structured search strategy, predefined eligibility criteria, and systematic data extraction. It is covering randomized controlled trials (RCTs) including training exercises distributed on touchscreens and published between 2016 and 2025 in Google Scholar, PubMed, Cochrane, and ScienceDirect databases. This period was determined to encompass the latest developments in recent touchscreen interventions, as these had become widely popular among the target population during this time. The selection of articles was carried out by a reviewer (the first author), respecting the inclusion and exclusion criteria to ensure a strict and transparent process. The search string was (“cognitive training” OR “cognitive stimulation” OR “brain training” OR “memory training” OR “game training”) AND (“senior” OR “older adults” OR “elder” OR “aging”) AND (“touchscreen” OR “smartphone” OR “tablet” OR “mobile device” OR “touch”) AND (“randomized controlled trial” OR “RCT” OR “clinical trial”). Octoparse software was utilized to extract articles in tabular format and process duplicates. The language and thematic relevance of the titles were analyzed manually.
Inclusion criteria
Studies were included if: (1) Participants were 65 years or older; (2) They maintained their pharmacological treatment unchanged throughout the protocol; (3) Cognitive training was administered through touchscreen devices; (4) Published from January 2016 to January 2025; (5) written in English or French. Studies were excluded if: (1) technologies, outcomes, or methodologies were not clearly described; (2) they dealt with computerized intervention without cognitive exercise; (3) patients received pharmacological psycho-stimulants or drugs to enhance cognition.
Results
Study characteristics
Thirty-four studies, representing a total of 3011 participants, validated the inclusion criteria as shown in Fig. 1. Among them, two studies were added following expert consultation. These studies met the inclusion criteria but did not appear in the database search due to differences in indexing and terminology. Among the 34 studies, 38.24% were considered as a healthy elderly population, 32.35% with individuals subject to mild cognitive impairments, 17.65% with subjective cognitive disorder, and 14.71% with people with dementia. 88.24% of studies used an examination tool for the inclusion of participants (17 with the Mini-Mental State Examination [MMSE] and 16 with the Montreal Cognitive Assessment [MoCA]). We also emphasize that 29.41% of studies studied the psychological profile of participants with the Geriatric Depression Scale (GDS). Baseline characteristics of participants are presented in Table 1 while the intervention characteristics are in Table 2 and the post measures in Table 3.
Quality and risk of bias
The quality and evidence in the included studies were assessed using the Rob2: Cochrane risk of bias tool for randomized trials [58]. We only kept for analysis studies without any high risk as presented in Fig. 2. The findings revealed that studies exhibited methodological bias, with 61.76% of them presenting some concerning features. The main reason for the problem of bias within the studies pertains to the lack of a protocol registered before the intervention (Domain 5). We also mention some concerns for 23.53% of studies regarding the randomization process not sufficiently explicitly presented (Domain 1).
Protocol divergence
Depending on the experiments, numerous protocol differences are utilized, and the measurement tools vary according to the studies. The most studied cognitive improvements are overall cognition with MMSE in 32.35% of cases, then inhibition and selective attention with Stroop in 20.59% of studies. Regarding the effect of interventions on mental health, depression is also measured in 11.76% of protocols, as shown in Table 3. A majority of studies do not use complementary treatments during the intervention. However, 41.18% conducted tests with one or more intervention protocols: 1 was carried out with participants undergoing pharmacological treatments, and 13 combined cognitive exercises with other non-pharmacological treatments (notably 9 with physical exercises and 5 with psycho-education). In terms of interfaces, 88.24% of studies employed tablets, while 14.71% of studies utilized smartphones and 8.82% employed touch tables. The duration of the training extended beyond 3 months in 41.18% of the studies, lasted between 1 and 3 months in 47.06%, and less than 1 month in 8.82% of the studies. The frequency of training sessions also varied, between less than two sessions per week in 14.71% of studies, while most of them required 3 to 6 sessions per week (82.35%). Otherwise, intervention was administered daily (2.94%). The prescribed duration per procedure ranged from 15 to 120 min, with most lasting between 15 and 45 min (64.71%). Training sessions were either supervised or unsupervised by a healthcare professional, with 44.12% of programs under controlled conditions, while others focused on autonomy or home care. The majority of studies employed a single control group; only 14.71% of them used more than one control group for analysis. There are also discrepancies regarding the type of control group used. 58.82% of studies used an active control group, 29.41% a waitlist group, and 23.53% a treatment as usual group.
Post-intervention results analysis
The thirty-four studies were included for data extraction and meta-analysis, taking into account the characteristics of the participants and the training programs. These studies utilized distinct cognitive and psychological state measures. Notably, the MMSE was employed as an outcome measure in 32.35% of studies, the MoCA in 17.65%, and the Geriatric Depression Scale (GDS) in 11.76%. Scores on cognition-related tests were also kept with the results of the Stroop in 20.59% of the studies, the n-back presented in 20.59%, the Digit Span in 17.65%, and the Trail Making Test in 17.65% of them.
General cognitive assessment
A total of six studies involving 355 participants (179 in the experimental group and 176 in the control groups) were utilized to analyze the post-intervention MMSE score. The improving results after intervention are statistically significant (mean difference: 1.76, 95% CI from 1.42 to 2.10, p \(\le \) 0.00001) with, however, a strong heterogeneity inherent to the variability of the studies (I2 = 91%), see Fig. 3. Besides, analysis of the results of studies utilizing the MoCA as an indicator of global cognition involves 5 studies with 305 participants (154 in interventions and 151 in control groups). The post-intervention improvement is statistically significant (mean difference: 1.99, 95% CI from 1.37 to 2.61, p \(\le \) 0.00001) as shown in Fig. 4.
Performance cognitive tasks
A total of 3 studies involving 457 participants (228 in the experimental group and 229 in the control groups) were utilized to analyze post-intervention scores on the digit span (DS), and the results were found to be statistically significant (mean difference: 0.61, 95% CI from 0.08 to 1.14, p \(\le \) 0.02). The results are presented in Fig. 5. 4 studies involving a total of 214 participants (115 in the experimental group and 99 in the control groups) were utilized to analyze post-intervention scores on the Trail Making Test and the results were found to be statistically significant (mean difference: −2.60, 95% CI from −3.56 to −1.65, p < 0.00001). The results are presented in Fig. 6. Concerning the other tests, the results were not statistically significant or analysis used different metrics not generalizable (i.e time, score, difference).
Discussion
Main results
The results of this review about computerized cognitive training via touchscreen present four main conclusions. 1: A small effect of computerized cognitive training programs on global cognition measured by MMSE and MoCA, but limited by the sample size. This result does not allow us to conclude on the contribution of computerized programs to overall cognition [34]. 2: A statistically significant improvement in the Digit Span in post-intervention. This result shows a significant effect of interventions on short-term and working memory. 3: A statistically significant improvement in the Trail Making Test in post-intervention. This suggests an improvement in processing speed, attention, and flexibility after cognitive training on touchscreens. 4: A statistically significant improvement in the Geriatric Depression Scale, as presented in Fig. 7, suggested an impact of these interventions on depressive mood.
Adherence in touchscreen cognitive trainings
A number of studies have already demonstrated that participants exhibit a lack of adherence to the cognitive training program in the long term. Thanks to the use of a more flexible solution characterized by touchscreens and gamified exercises, better results were expected. However, a substantial proportion of the examined studies report a significant percentage of dropouts. Several measurements were performed in the studies to estimate the adherence rate based on the individual characteristics of the participants. Baquero et al. [61] specify that they found no statistically significant relationship between a physical health variable and a person’s adherence to a computerized cognitive training program. Concerning the number of years of schooling, while some studies appear to emphasize a relationship between that factor and the public’s adherence to cognitive reeducation programs [61, 64] while others have not reported a link [65]. Future studies on computerized cognitive training ought to consider this difficulty to validate performance results.
Methodological caveats on touchscreen cognitive training
Quite a number of reviews have previously delineated methodological concerns pertaining to computerized cognitive training [41, 42]. It was hypothesized that implementing training on touchscreens had the capacity to facilitate the execution of strict protocols limiting attribution bias. Regretably, quite a number of biases were uncovered in this review. Difficulty in obtaining a sufficient sample size constitutes the primary stumbling blocks of conclusions in 61.76% of studies. The dematerialization of interventions does not appear to directly allow the membership of a significant group of individuals, nor the retention of a significant part of the initial sample. This renders the establishment of the requisite control groups unfeasible (waiting list and active control group). The use of well-designed control groups is an indispensable element of studies on computerized cognitive training inasmuch as placebo effects and participant expectations can influence observed outcomes [26, 66]. The presence of an active control group is important to ensure the valid interpretation of cognitive training. However, the presence of an active control group is not taken into account in a number of studies (29.41%), a methodological weakness emphasized in other reviews [59]. Especially since in a proportion of studies, the results attributable to the intervention program were not statistically significant when compared with the performance of an active control group [60, 63]. This suggests that the choice of the active control group must be carefully considered to highlight the mechanisms specific to computerized cognitive training programs compared to other numerical tasks [47]. However, when active control groups are not appropriately designed, it becomes difficult to establish intervention-specific effects against placebo effects [27]. Future studies should endeavor to obtain a more substantial sample of participants and emphasize the importance of implementing strict control groups. Furthermore, homogeneity or paucity of representativeness of the sample is frequently emphasized. In our sample, this feature characterized 44.12% of studies. For instance, gender proportionality is seldom attained despite some studies indicating a first-order relationship between gender and cognitive decline [67, 68].
Controlling external stimuli during interventions assumes paramount importance during unsupervised or independent interventions, and the diversity of program admissions is a weighty element to consider in the analysis of results. Initiating home studies confers an advantage in terms of access to patients whose physical condition or geolocation might otherwise preclude intervention in the center [61, 69]. Conversely, this administration of computerized cognitive training provides variability to program allocation models. Payne et al. [62] demonstrated that gains in processing speed in the home-based group reached 74.00% of those in the laboratory training. Finally, effects monitoring studies are not carried out systematically, despite the necessity to validate the long-term acquisition and transfer effects, given the ongoing debates on the effects of computerized cognitive training [41, 42]. About the results’ probable positive effect on “near transfer,” that is to say, on untrained tasks alike, disagreement remains present concerning the capacity for “far transfer” on more distant tasks requiring the same cognitive processes after a computerized cognitive training program [60, 70]. Nevertheless, few studies in our sample examined the transfer in their respective protocols. Furthermore, when transfer effects are studied, divergent results are frequently presented [59]. This may partly reflect, as for computerized cognitive training, the variability inherent to the transfer effects validation tasks. For example, Boujut et al. [80] employed virtual reality to examine the assessment of cognitive processes on a simulation of daily life tasks while Ballesteros et al. [59] used the same touchscreen platform with dedicated tasks included in the programs to examine the transfer. Among the studies considered, a third of them employed a multimodal training program. These programs refer to work suggesting that multimodal interventions may be more promising for cognitive improvement [71]. As pertinent as this approach might be, it does not justify the specific effectiveness of computerized cognitive training programs included in a global intervention.
Consideration of accessibility and usability
Motivation is a crucial factor of adherence to the program among seniors [72]. Furthermore, patients’ reduced engagement in cognitive training has been associated with the difficulty to perform exercises due to the symptoms of their condition [38]. Its importance is heightened by the context of remediation in cognitive sciences, as such programs typically require sustained and long-term participation to demonstrate efficiency [73]. This suggests that the user-friendliness and accessibility of computerized cognitive training programs are variables to consider to measure the effectiveness of treatments. Nonetheless, only few studies examine the accessibility of solutions before the prescription of the programs [80]. The present study focused specifically on computerized cognitive training programs presented on touchscreens. This follows the various works justifying the quality of these interfaces for individuals subject to cognitive disorders, as already highlighted by the first works in 1986 [18, 74, 75]. However, this is not sufficient, and computerized cognitive training ought to further consider personalization within programs [38]. This could be achieved with the integration of accessibility support tools, such as constant assistance or adaptation tools like Zoom [53]. This approach is not without introducing an additional complexity consisting of studying the multi-objective problem of minimizing accessibility difficulties in parallel with the quality of a remediation program. To facilitate the integration of patients in this approach, psycho-education approaches as well as opening to various highly personalized programs facilitating the participation of users should be considered [18, 47]. Another important point concerns the personalization and adaptation of computerized cognitive exercises on touchscreens according to the patient’s profile. Adapting the level of difficulty, the content, and user feedback can positively impact both engagement and the effectiveness of this type of intervention. Integrating adaptation algorithms and following a user-centered approach can improve the efficiency and long-term persistence of the exercises.
Strengths and limitations
The first strength of this study was to focus exclusively on RCTs applied on touchscreens attributions. Due to methodological limitations, we chose an analysis specifically focused on RCTs. The transition to computerized cognitive training on touchscreens enables the consideration of the implementation of cognitive training programs at home and the administration of the programs on interfaces accessible to people subject to cognitive disorders. However, the results of this review are limited by the number of included studies and the small average study sample size. Another limitation of the review is that publication bias was not addressed. Despite including 34 studies, the number of studies per outcome is insufficient to develop a funnel plot or Egger’s test. Moreover, even if we only retained the RCTs, the methodologies applied are variable, in addition to encountering problems related to protocol difficulties. A pronounced heterogeneity was also observed among the results between experiments. This postulate prevents the claimed results from being strictly validated. Additionally, our review included language restrictions and a limited time frame (9 years) to narrow the scope to more modern and improved accessibility interfaces, ignoring consumer touchscreens that have appeared since 2010. For these reasons, it is difficult to draw conclusions on the contribution of computerized cognitive training on a touchscreen even if the preliminary results seem to justify an interest in prevention and cognitive decline. Overall, the certainty of the evidence presenting computerized cognitive training on touchscreens as a tool for cognitive remediation is low to moderate. This result reflects the small sample sizes, identified concerns about the risk of bias, and the heterogeneity of the protocols and outcomes measured. Although 19 studies reported follow-up outcomes, these were short-term results, ranging from 1 week to 3 months. Therefore, the long-term effectiveness of cognitive interventions cannot be established. Future research incorporating long-term follow-up is needed.
Conclusion
The results of this review demonstrate that computerized cognitive training administered on a touchscreen appears to be feasible and adhered to by a large proportion of seniors. Their utilization appears to be beneficial for a consequent percentage of that population. However, many of the issues presented in reviews targeting cognitive training are also persisting in this context. The effects on overall cognition and on specific cognitive processes such as episodic memory and working memory are visible and significant. At the same time, notable positive results were uncovered for short-term memory and attention. However, the methodological difficulties and the variability of practices prevent us from strictly concluding on the effectiveness of playful cognitive training on touchscreens. Conversely, subsequent work should explore the correlation between accessibility of program distribution environments and the outcomes on performance attributable to training, as well as the unique characteristics of the patient’s initial conditions.
Data availability
Not applicable.
References
World Health Organization. Ageing and health; 2021. Retrieved from https://www.who.int/news-room/fact-sheets/detail/ageing-and-health.
Geneva: World Health Organization. Global status report on the public health response to dementia; 2021. Retrieved from https://www.who.int/publications/i/item/9789240033245
American Society on Aging and MetLife Foundation. Attitudes and awareness of brain health poll. San Francisco, CA: American Society on Aging; 2006. Retrieved from https://brainhealthctr.com/wp-content/uploads/2019/08/brainhealthpoll.pdf
Shin M, Lee A, Cho AY, Son M, Kim YH. Effects of process-based cognitive training on memory in the healthy elderly and patients with mild cognitive impairment: a randomized controlled trial. Psychiatry Investig. 2020;17(8):751–61. https://doi.org/10.30773/pi.2019.0225.
Elboim-Gabyzon M, Weiss PL, Danial-Saad A. Effect of age on the touchscreen manipulation ability of community-dwelling adults. Int J Environ Res Public Health. 2021;18(4):2094. https://doi.org/10.3390/ijerph18042094.
Nouchi R, Saito T, Nouchi H, Kawashima R. Small acute benefits of 4 weeks processing speed training games on processing speed and inhibition performance and depressive mood in the healthy elderly people: evidence from a randomized control trial. Front Aging Neurosci. 2016;8:302. https://doi.org/10.3389/fnagi.2016.00302.
Contador I, Bermejo-Pareja F, Mitchell AJ, Trincado R, Villarejo A, Sánchez-Ferro Á, et al. Cause of death in mild cognitive impairment: a prospective study (NEDICES). Eur J Neurol. 2014;21(2):253-e9. https://doi.org/10.1111/ene.12278.
Chan PT, Chang WC, Chiu HL, Kao CC, Liu D, Chu H, et al. Effect of interactive cognitive-motor training on eye-hand coordination and cognitive function in older adults. BMC Geriatr. 2019;19(1):27. https://doi.org/10.1186/s12877-019-1029-y.
Baddeley A. Working memory: theories, models, and controversies. Annu Rev Psychol. 2012;63:1–29. https://doi.org/10.1146/annurev-psych-120710-100422.
Nguyen CM, Copeland CT, Lowe DA, Heyanka DJ, Linck JF. Contribution of executive functioning to instrumental activities of daily living in older adults. Appl Neuropsychol Adult, 2019;27(1-8). https://doi.org/10.1080/23279095.2018.1550408
Abd-Alrazaq A, Ahmed A, Alali H, Aldardour AM, Househ M. The effectiveness of serious games on cognitive processing speed among older adults with cognitive impairment: systematic review and meta-analysis. JMIR serious games. 2022;10(3). https://doi.org/10.2196/36754.
Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, et al. Alzheimer’s disease cooperative study group. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005;352(23):2379–88. https://doi.org/10.1056/NEJMoa050151.
Winblad B, Gauthier S, Scinto L, Feldman H, Wilcock GK, Truyen L, et al. GAL-INT-11/18 study group. Safety and efficacy of galantamine in subjects with mild cognitive impairment. Neurology. 2008;70(22):2024–35. https://doi.org/10.1212/01.wnl.0000303815.69777.26.
Golomb J, Kluger A, Ferris SH. Mild cognitive impairment: historical development and summary of research. Dialogues Clin Neurosci. 2004;6(4):351–67. https://doi.org/10.31887/DCNS.2004.6.4/jgolomb.
Ballard C, Corbett A. Management of neuropsychiatric symptoms in people with dementia. CNS Drugs. 2010;24(9):729–39. https://doi.org/10.2165/11319240-000000000-00000.
Reuter-Lorenz PA, Park DC. How does it STAC Up? Revisiting the scaffolding theory of aging and cognition. Neuropsychol Rev. 2014;24(3):355–70. https://doi.org/10.1007/s11065-014-9270-9.
Li HJ, Hou XH, Liu HH, Yue CL, Lu GM, Zuo XN. Putting age-related task activation into large-scale brain networks: a meta-analysis of 114 fMRI studies on healthy aging. Neurosci Biobehav Rev. 2014;57:156–74. https://doi.org/10.1016/j.neubiorev.2015.08.013.
Irazoki E, Contreras-Somoza LM, Toribio-Guzmán JM, Jenaro-Río C, van der Roest H, Franco-Martín MA. Technologies for cognitive training and cognitive rehabilitation for people with mild cognitive impairment and dementia. Syst Rev Front Psychol. 2020;11:648. https://doi.org/10.3389/fpsyg.2020.00648.
Li HJ, Hou XH, Liu HH, Yue CL, Lu GM, Zuo XN. Putting age-related task activation into large-scale brain networks: a meta-analysis of 114 fMRI studies on healthy aging. Neurosci Biobehav Rev. 2015;57:156–74. https://doi.org/10.1016/j.neubiorev.2015.08.013.
Yaakov S. Cognitive reserve. Neuropsychologia. 2009;47(10):2015–28. https://doi.org/10.1016/j.neuropsychologia.2009.03.004.
Sampedro-Piquero P, Begega A. Environmental enrichment as a positive behavioral intervention across the lifespan. Curr Neuropharmacol. 2017;15(4):459–70. https://doi.org/10.2174/1570159X14666160325115909.
Gates N, Valenzuela M. Cognitive exercise and its role in cognitive function in older adults. Curr Psychiatry Rep. 2010;12(1):20–7. https://doi.org/10.1007/s11920-009-0085-y.
Wykes T, Huddy V, Cellard C, McGurk SR, Czobor P. A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. Am J Psychiatry. 2011;168(5):472–85. https://doi.org/10.1176/appi.ajp.2010.10060855.
Reijnders J, van Heugten C, van Boxtel M. Cognitive interventions in healthy older adults and people with mild cognitive impairment: a systematic review. Ageing Res Rev. 2013;12(1):263–75. https://doi.org/10.1016/j.arr.2012.07.003.
Di Lorito C, Duff C, Rogers C, Tuxworth J, Bell J, Fothergill R, et al. Tele-rehabilitation for people with dementia during the COVID-19 pandemic: a case-study from England. Int J Environ Res Public Health. 2021;18(4):1717. https://doi.org/10.3390/ijerph18041717.
Foroughi CK, Monfort SS, Paczynski M, McKnight PE, Greenwood PM. Placebo effects in cognitive training. Proc Natl Acad Sci USA. 2016;113(27):7470–4. https://doi.org/10.1073/pnas.1601243113.
Simons DJ, Boot WR, Charness N, Gathercole SE, Chabris CF, Hambrick DZ, et al. Do “brain-training” programs work? Psychol Sci Public Interest. 2016;17(3):103–186. https://doi.org/10.1177/1529100616661983.
Miller KJ, Dye RV, Kim J, Jennings JL, O’Toole E, Wong J, et al. Effect of a computerized brain exercise program on cognitive performance in older adults. Am J Geriatric Psych Official J Am Assoc Geriatric Psych. 2013;21(7):655–63. https://doi.org/10.1016/j.jagp.2013.01.077.
Gates NJ, Vernooij RWM, Di Nisio M, Karim S, March E, Martínez G, et al. Computerised cognitive training for preventing dementia in people with mild cognitive impairment. Cochrane Database Syst Rev. 2019;3(3):CD012279. https://doi.org/10.1002/14651858.CD012279.pub2.
Liapis J, Harding KE. Meaningful use of computers has a potential therapeutic and preventative role in dementia care: a systematic review. Australas J Ageing. 2017;36(4):299–307. https://doi.org/10.1111/ajag.12446.
Meiland F, Innes A, Mountain G, Robinson L, van der Roest H, García-Casal JA, et al. Technologies to support community-dwelling persons with dementia: a position paper on issues regarding development, usability, effectiveness and cost-effectiveness, deployment, and ethics. JMIR Rehabil Assist Technol. 2017;4(1). https://doi.org/10.2196/rehab.6376.
Ballesteros S, Kraft E, Santana S, Tziraki C. Maintaining older brain functionality: a targeted review. Neurosci Biobehav Rev. 2015;55:453–77. https://doi.org/10.1016/j.neubiorev.2015.06.008.
Shah TM, Weinborn M, Verdile G, Sohrabi HR, Martins RN. Enhancing cognitive functioning in healthy older adults: a systematic review of the clinical significance of commercially available computerized cognitive training in preventing cognitive decline. Neuropsychol Rev. 2017;27(1):62–80. https://doi.org/10.1007/s11065-016-9338-9.
Lampit A, Hallock H, Valenzuela M. Computerized cognitive training in cognitively healthy older adults: a systematic review and meta-analysis of effect modifiers. PLoS Med. 2014;11(11):e1001756. https://doi.org/10.1371/journal.pmed.1001756.
Ge S, Zhu Z, Wu B, McConnell ES. Technology-based cognitive training and rehabilitation interventions for individuals with mild cognitive impairment: a systematic review. BMC Geriatr. 2018;18(1):213. https://doi.org/10.1186/s12877-018-0893-1.
Li R, Geng J, Yang R, Ge Y, Hesketh T. Effectiveness of computerized cognitive training in delaying cognitive function decline in people with mild cognitive impairment: systematic review and meta-analysis. J Med Internet Res. 2022;24(10). https://doi.org/10.2196/38624.
Bottiroli S, Cavallini E. Can computer familiarity regulate the benefits of computer-based memory training in normal aging? A study with an Italian sample of older adults. Neuropsychol Dev Cogn Section B Aging Neuropsychol Cogn. 2009;16(4):401–18. https://doi.org/10.1080/13825580802691763.
Tak S. In quest of tablet apps for elders with Alzheimer’s disease: a descriptive review. Comput Inf Nursing CIN. 2022;39(7):347–54. https://doi.org/10.1097/CIN.0000000000000718.
Dequanter S, Gagnon MP, Ndiaye MA, Gorus E, Fobelets M, Giguère A, et al. The effectiveness of e-health solutions for aging with cognitive impairment: a systematic review. Gerontologist. 2021;61(7):e373–94. https://doi.org/10.1093/geront/gnaa065.
Wang P, Fang Y, Qi JY, Li HJ. FISHERMAN: a serious game for executive function assessment of older adults. Assessment. 2022;30:10731911221105648. https://doi.org/10.1177/10731911221105648.
Harvey PD, McGurk SR, Mahncke H, Wykes T. Controversies in computerized cognitive training. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;3(11):907–15. https://doi.org/10.1016/j.bpsc.2018.06.008.
Lampit A, Valenzuela M, Gates NJ. Computerized cognitive training is beneficial for older adults. J Am Geriatr Soc. 2015;63(12):2610–2. https://doi.org/10.1111/jgs.13825.
Yeo PS, Nguyen TN, Ng MPE, Choo RWM, Yap PLK, Wee SL. Evaluation of the implementation and effectiveness of community-based brain-computer interface cognitive group training in healthy community-dwelling older adults: randomized controlled implementation trial. JMIR Format Res. 2021;5(4). https://doi.org/10.2196/25462.
Nozawa T, Taki Y, Kanno A, Akimoto Y, Ihara M, Yokoyama R, et al. Effects of different types of cognitive training on cognitive function, brain structure, and driving safety in senior daily drivers: a pilot study. Behav Neurol. 2015;2015. https://doi.org/10.1155/2015/525901.
Voss MW, Erickson KI, Prakash RS, Chaddock L, Kim JS, Alves H, et al. Neurobiological markers of exercise-related brain plasticity in older adults. Brain Behav Immun. 2013;28:90–9. https://doi.org/10.1016/j.bbi.2012.10.021.
Erickson KI, Miller DL, Roecklein KA. The aging hippocampus: interactions between exercise, depression, and BDNF. Neurosci Rev J Bringing Neurobiol Neurol Psych. 2011;18:82–97. https://doi.org/10.1177/1073858410397054.
Kalbe E, Bintener C, Ophey A, Reuter C, Göbel S, Klöters S, et al. Computerized cognitive training in healthy older adults: baseline cognitive level and subjective cognitive concerns predict training outcome. Health. 2018;10:20–55. https://doi.org/10.4236/health.2017.101003.
Oh SJ, Seo S, Lee JH, Song MJ, Shin MS. Effects of smartphone-based memory training for older adults with subjective memory complaints: a randomized controlled trial. Aging Mental Health. 2018;22(4):526–34. https://doi.org/10.1080/13607863.2016.1274373.
Toril P, Reales JM, Ballesteros S. Video game training enhances cognition of older adults: a meta-analytic study. Psychol Aging. 2014;29(3):706–16. https://doi.org/10.1037/a0037507.
Laamarti F, Eid M, El Saddik A. An overview of serious games. Int J Comput Games Technol. 2014;706–16. https://doi.org/10.1155/2014/358152.
Savulich G, Piercy T, Fox C, Suckling J, Rowe JB, O’Brien JT, et al. Cognitive training using a novel memory game on an iPad in patients with amnestic mild cognitive impairment (aMCI). Int J Neuropsychopharmacol. 2017;20(8):624–33. https://doi.org/10.1093/ijnp/pyx040.
Groenewoud H, de Lange J, Schikhof Y, Astell A, Joddrell P, Goumans M. People with dementia playing casual games on a tablet. Gerontechnology. 2017;16:37–47. https://doi.org/10.4017/gt.2017.16.1.004.00.
Cristina E, Almao C. Evaluating mobile apps designed for the elderly people based on available usability and accessibility guidelines; 2018.
Jang H, Yeo M, Cho J, Kim S, Chin J, Kim HJ, et al. Effects of smartphone application-based cognitive training at home on cognition in community-dwelling non-demented elderly individuals: a randomized controlled trial. Alzheimers Dement (N Y). 2021;7(1). https://doi.org/10.1002/trc2.12209.
Brinke LFT, Davis JC, Barha CK, Liu-Ambrose T. Effects of computerized cognitive training on neuroimaging outcomes in older adults: a systematic review. BMC Geriatr. 2017;17(1):139. https://doi.org/10.1186/s12877-017-0529-x.
Bo W, Lei M, Tao S, Jie LT, Qian L, Lin FQ, et al. Effects of combined intervention of physical exercise and cognitive training on cognitive function in stroke survivors with vascular cognitive impairment: a randomized controlled trial. Clin Rehabil. 2019;33(1):54–63. https://doi.org/10.1177/0269215518791007.
Yu R, Leung G, Woo J. Randomized controlled trial on the effects of a combined intervention of computerized cognitive training preceded by physical exercise for improving frailty status and cognitive function in older adults. Int J Environ Res Public Health. 2021;18(4):1396. https://doi.org/10.3390/ijerph18041396.
Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.
Ballesteros S, Mayas J, Prieto A, Ruiz-Marquez E, Toril P, Reales JM. Effects of video game training on measures of selective attention and working memory in older adults: results from a randomized controlled trial. Front Aging Neurosci. 2017;9:354. https://doi.org/10.3389/fnagi.2017.00354.
Meltzer JA, Rose MK, Le AY, Spencer KA, Goldstein L, Gubanova A, et al. Improvement in executive function for older adults through smartphone apps: a randomized clinical trial comparing language learning and brain training. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2021;30(2):150–71. https://doi.org/10.1080/13825585.2021.1991262.
Baquero AAD, Bartolomé MVP, Toribio-Guzmán JM, Martínez-Abad F, Vidales EP, Aguado YB, et al. Determinants of adherence to a “GRADIOR” computer-based cognitive training program in people with mild cognitive impairment (MCI) and mild dementia. J Clin Med. 2022;11(6):1714. https://doi.org/10.3390/jcm11061714.
Payne BR, Stine-Morrow EAL. The effects of home-based cognitive training on verbal working memory and language comprehension in older adulthood. Front Aging Neurosci. 2017;9:256. https://doi.org/10.3389/fnagi.2017.00256.
Turconi MM, Vella F, Mosetti F. Efficacy of tablet-based applications for mental training in preserving cognitive abilities of older adults. AboutOpen. 2019;6:24–30. https://doi.org/10.33393/abtpn.2019.282.
Shatil E. Does combined cognitive training and physical activity training enhance cognitive abilities more than either alone? A four-condition randomized controlled trial among healthy older adults. Front Aging Neurosci. 2013;5:8. https://doi.org/10.3389/fnagi.2013.00008.
Turunen M, Hokkanen L, Bäckman L, Stigsdotter-Neely A, Hänninen T, Paajanen T, et al. Computer-based cognitive training for older adults: determinants of adherence. PLoS ONE. 2019;14(7). https://doi.org/10.1371/journal.pone.0219541.
Sala G, Aksayli D, Tatlidil KS, Tatsumi T, Gondo Y, Gobet F. Near and far transfer in cognitive training: a second-order meta-analysis. Collabra: Psychol. 2019;5(18). https://doi.org/10.1525/collabra.203
Zuelke AE, Riedel-Heller SG, Wittmann F, Pabst A, Roehr S, Luppa M. Gender-specific design and effectiveness of non-pharmacological interventions against cognitive decline and dementia-protocol for a systematic review and meta-analysis. PLoS ONE. 2021;16(8):e0256826. https://doi.org/10.1371/journal.pone.0256826.
Wang L, Tian T. Alzheimer’s disease neuroimaging initiative. Gender differences in elderly with subjective cognitive decline. Front Aging Neurosci. 2018;10:166. https://doi.org/10.3389/fnagi.2018.00166.
Blackwood J, Shubert T, Fogarty K, Chase C. The impact of a home-based computerized cognitive training intervention on fall risk measure performance in community dwelling older adults, a pilot study. J Nutr Health Aging. 2016;20(2):138–45. https://doi.org/10.1007/s12603-015-0598-5.
Teixeira-Santos AC, Moreira CS, Magalhães R, Magalhães C, Pereira DR, Leite J, et al. Reviewing working memory training gains in healthy older adults: a meta-analytic review of transfer for cognitive outcomes. Neurosci Biobehav Rev. 2019;103:163–77. https://doi.org/10.1016/j.neubiorev.2019.05.009.
Olanrewaju O, Clare L, Barnes L, Brayne C. A multimodal approach to dementia prevention: a report from the Cambridge Institute of Public Health. Alzheimers Dement (N Y). 2015;1(3):151–6. https://doi.org/10.1016/j.trci.2015.08.003.
Ijsselsteijn WA, Nap HH, Kort Y, Poels K. Digital game design for elderly users. Conference on Future Play; 2007.
Vermeir JF, White MJ, Johnson D, Crombez G, Van Ryckeghem DML. The effects of gamification on computerized cognitive training: systematic review and meta-analysis. JMIR Serious Games. 2020;8(3). https://doi.org/10.2196/18644.
Hitch D, Swan J, Pattison R, Stefaniak R. Use of touchscreen tablet technology by people with dementia in homes: a scoping review. J Rehabil Assist Technol Eng. 2017;31(4):2055668317733382. https://doi.org/10.1177/2055668317733382.
Joddrell P, Astell AJ. Studies involving people with dementia and touchscreen technology: a literature review. JMIR Rehabil Assist Technol. 2016;3(2). https://doi.org/10.2196/rehab.5788.
Antonenko D, Fromm AE, Thams F, Kuzmina A, Backhaus M, Knochenhauer E, et al. Cognitive training and brain stimulation in patients with cognitive impairment: a randomized controlled trial. Alzheimer’s Res Therapy. 2024;16(1):6. https://doi.org/10.1186/s13195-024-01381-3.
Asada T, Tanaka M, Araki W, Jon Lebowitz A, Kakuma T. Efficacy and concurrent validity of computerized brain training based on everyday living (BTEL) based on instrumental activities of living for cognitively healthy old individuals: a preliminary study. Journal of Alzheimer’s disease JAD. 2024;99(2):549–58. https://doi.org/10.3233/JAD-231165.
Baik JS, Min JH, Ko SH, Yun MS, Lee B, Kang NY, et al. Effects of home-based computerized cognitive training in community-dwelling adults with mild cognitive impairment. IEEE J Trans Eng Health Med. 2023;12:97–105. https://doi.org/10.1109/JTEHM.2023.3317189.
Belleville S, Cuesta M, Bieler-Aeschlimann M, Giacomino K, Widmer A, Mittaz Hager AG, et al. Pre-frail older adults show improved cognition with StayFitLonger computerized home-based training: a randomized controlled trial. GeroScience. 2023;45(2):811–22. https://doi.org/10.1007/s11357-022-00674-5.
Boujut A, Verty LV, Maltezos S, Lussier M, Mellah S, Bherer L, et al. Effects of computerized updating and inhibition training in older adults: the ACTOP three-arm randomized double-blind controlled trial. Front Neurol. 2020;11. https://doi.org/10.3389/fneur.2020.606873.
Brill E, Holfelder A, Falkner M, Krebs C, Brem AK, Klöppel S. Behavioural and neuronal substrates of serious game-based computerised cognitive training in cognitive decline: randomised controlled trial. BJPsych Open. 2024;10(6):e200. https://doi.org/10.1192/bjo.2024.797.
Callisaya ML, Jayakody O, Vaidya A, Srikanth V, Farrow M, Delbaere K. A novel cognitive-motor exercise program delivered via a tablet to improve mobility in older people with cognitive impairment - StandingTall Cognition and Mobility. Exp Gerontol. 2021;152:111434. https://doi.org/10.1016/j.exger.2021.111434.
Cardullo, S. New frontiers in neuropsychology. The Padua Rehabilitation Tool: a new software for rehabilitation using touch-screen technology; 2017.
Chae HJ, Lee SH. Effectiveness of the online-based comprehensive cognitive training application, smart brain, for community-dwelling older adults with dementia: a randomized controlled trial. Eur J Phys Rehabil Med. 2024;60(3):423–32. https://doi.org/10.23736/S1973-9087.24.08043-2.
Contrada M, Arabia G, Vatrano M, Pucci C, Mantia I, Scarfone F, et al. Multidomain cognitive tele-neurorehabilitation training in long-term post-stroke patients: an RCT study. Brain Sci. 2025;15(2):145. https://doi.org/10.3390/brainsci15020145.
Fabara-Rodríguez AC, García-Bravo C, García-Bravo S, Quirosa-Galán I, Rodríguez-Pérez MP, Pérez-Corrales J, et al. Quality-of-life- and cognitive-oriented rehabilitation program through NeuronUP in older people with Alzheimer’s disease: a randomized clinical trial. J Clin Med. 2024;13(19):5982. https://doi.org/10.3390/jcm13195982.
Funghi G, Meli C, Cavagna A, Bisoffi L, Zappini F, Papagno C, et al. The Social and Cognitive Online Training (SCOT) project: a digital randomized controlled trial to promote socio-cognitive well-being in older adults. Arch Gerontol Geriatr. 2024;122. https://doi.org/10.1016/j.archger.2024.105405.
Hicks C, Smith N, Ratanapongleka M, Menant J, Turner J, Lo J, Garcia J, Valenzuela M, Chaplin C, Delbaere K, Herber R, Sherrington C, Toson B, Lord S, Sturnieks D. smart\(\pm \)step exergame and seated computer brain training for preventing falls in community-dwelling older people: a 12-month randomised controlled trial; 2023. https://doi.org/10.21203/rs.3.rs-2852524/v1.
Jaeggi SM, Weaver AN, Carbone E, Trane FE, Smith-Peirce RN, Buschkuehl M, et al. EngAge – s metacognitive intervention to supplement working memory training: a feasibility study in older adults. Aging Brain. 2023;4. https://doi.org/10.1016/j.nbas.2023.100083.
Kang JM, Kim N, Yun SK, Seo HE, Bae JN, Kim WH, et al. Exploring transfer effects on memory and its neural mechanisms through a computerized cognitive training in mild cognitive impairment: randomized controlled trial. Psychogeriat Official J Japanese Psychogeriat Soc. 2024;24(5):1075–86. https://doi.org/10.1111/psyg.13161.
Kao CC, Chiu HL, Liu D, Chan PT, Tseng IJ, Chen R, et al. Effect of interactive cognitive motor training on gait and balance among older adults: a randomized controlled trial. Int J Nurs Stud. 2018;82:121–8. https://doi.org/10.1016/j.ijnurstu.2018.03.015.
Klaming L, Robbemond L, Lemmens P, Hart de Ruijter E. Digital compensatory cognitive training for older adults with memory complaints. Activities Adapt Aging. 2022;47(1):10–39. https://doi.org/10.1080/01924788.2022.2044989.
Lee J, Kim J, Park A, Hong RK, Ko M, Heo M, et al. Efficacy of a mobile-based multidomain intervention to improve cognitive function and health-related outcomes among older Korean adults with subjective cognitive decline. J Alzheimer’s Disease JAD. 2023;93(4):1551–62. https://doi.org/10.3233/JAD-221299.
Lim EH, Kim DS, Won YH, Park SH, Seo JH, Ko MH, Kim GW. Effects of home based serious game training (brain talk\(^{\rm TM}\)) in the elderly with mild cognitive impairment: randomized, a single-blind, controlled trial. Brain NeuroRehab, 2023;16(1):e4. https://doi.org/10.12786/bn.2023.16.e4.
Meltzer JA, Kates Rose M, Le AY, Spencer KA, Goldstein L, Gubanova A, et al. Improvement in executive function for older adults through smartphone apps: a randomized clinical trial comparing language learning and brain training. Neuropsychol Dev Cogn Section B Aging Neuropsychol Cogn. 2023;30(2):150–71. https://doi.org/10.1080/13825585.2021.1991262.
Mozafari M, Otaghi M, Paskseresht M, Vasiee A. Effect of video games on cognitive performance and problem-solving ability in the aged with cognitive dysfunction: a randomized clinical trial. Iranian J Med Sci. 2025;50(2):77–86. https://doi.org/10.30476/ijms.2024.101861.3452.
Rai HK, Schneider J, Orrell M. An individual cognitive stimulation therapy app for people with dementia and carers: results from a feasibility randomized controlled trial (RCT). Clin Interv Aging. 2021;16:2079–94. https://doi.org/10.2147/CIA.S323994.
Robert P, Manera V, Derreumaux A, Montesino FY, M., Leone, E., Fabre, R., & Bourgeois, J. Efficacy of a web app for cognitive training (MeMo) regarding cognitive and behavioral performance in people with neurocognitive disorders: randomized controlled trial. J Med Internet Res. 2020;22(3). https://doi.org/10.2196/17167.
Givon Schaham N, Buckman Z, Rand D. TECH preserves global cognition of older adults with MCI compared with a control group: a randomized controlled trial. Aging Clin Exp Res. 2024;36(1):1. https://doi.org/10.1007/s40520-023-02659-6.
Sosa GW, Lagana L. The effects of video game training on the cognitive functioning of older adults: a community-based randomized controlled trial. Arch Gerontol Geriatr. 2019;80:20–30. https://doi.org/10.1016/j.archger.2018.04.012.
Sutton E, Catling J, Zanten JJCSVV, Segaert K. Practice makes perfect, but to what end? Computerised brain training has limited cognitive benefits in healthy ageing. Psychol Res. 2025;89(2):75. https://doi.org/10.1007/s00426-025-02110-7.
Tsiakiri A, Ioannidis P, Vlotinou P, Kokkotis C, Megagianni S, Toumaian M, Terzoudi K, Koutzmpi V, Despoti A, Megari K, Liozidou A, Kyriazidoy S, Vadikolias K, Tsapanou A. The role of a computerized cognitive intervention program on the neuropsychiatric symptoms in mild cognitive impairment. Aging Med Healthcare, 2024;15:122-128. https://doi.org/10.33879/AMH.153.2023.01005.
Yang HL, Chu H, Kao CC, Miao NF, Chang PC, Tseng P, et al. Construction and evaluation of multidomain attention training to improve alertness attention, sustained attention, and visual-spatial attention in older adults with mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry. 2020;35(5):537–46. https://doi.org/10.1002/gps.5269.
Yang H-L, Chu H, Kao C-C, Chiu H-L, Tseng I-J, Tseng P, et al. Development and effectiveness of virtual interactive working memory training for older people with mild cognitive impairment: a single-blind randomised controlled trial. Age Ageing. 2019;48(4):519–25. https://doi.org/10.1093/ageing/afz029.
Yow WQ, Sou KL, Wong AC. A novel dual-language touch-screen intervention to slow down cognitive decline in older adults: a randomized controlled trial. Innov Aging. 2024;8(7):igae052. https://doi.org/10.1093/geroni/igae052.
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The authors of this article would like to thank the University of Angers and Blue Metrics for funding this research on a PhD study program in Applied Science for the main author.
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Macé, M., Amghar, T., Richard, P. et al. Computerized cognitive training on touchscreen for elderly: a systematic review of randomised controlled trials. GeroScience (2026). https://doi.org/10.1007/s11357-026-02132-y
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DOI: https://doi.org/10.1007/s11357-026-02132-y









