01/21/2026
research article
Here the authors present Histo-Miner, a framework designed to systematically analyze these images at multiple levels of detail—from one single cell to entire tissue regions.
Image credit: Sancéré et al
Current Issue December 2025
01/22/2026
research article
The authors use AlphaFold2-multimer to generate high-confidence predictions of PPIs in Drosophila melanogaster. They highlight the importance of incorporating often neglected functional associations when predicting protein-protein interactions at a genomic scale.
Image credit: Peng and Zhao
01/12/2026
research article
Despite differences between classification approaches and calls for the development of consensus methods, most analyses of shotgun metagenomics data for microbiome studies use a single taxonomic classifier.
Image credit: CDC
12/29/2025
research Article
Cellular imaging is widely used in biological studies, and often enables quantitative analysis of phenotypic variation through the use of machine learning algorithms. The authors introduce Cell-DINO, an adaptation of the DINOv2, and demonstrate its ability to produce better features for cell phenotyping problems.
Image credit: Moutakanni et al
12/16/2025
Education
Inspired by the success of freezer challenges to reduce the environmental footprint of frozen sample storage in labs, the authors developed the data cleaning challenge.
Image credit: Kal et al
11/11/2025
research article
As a well-established and extensively utilized model organism, C. elegans serves as a crucial platform for investigating behavioral regulation mechanisms and their biological significance. However, manually tracking the locomotor behavior of large numbers of C. elegans is both cumbersome and inefficient.
Image credit: Wikimedia
11/11/2025
research article
The authors are interested in understanding how bacteria regulate the expression of their genes independent of protein-based transcription factors.
Image credit: Taylor Leopold
11/07/2025
research article
Understanding microbial interactions is fundamental for exploring population dynamics, particularly in microbial communities...
Image credit: CDC
11/03/2025
research article
Genome-wide scans using small RNA-seq data often yield high rates of false-positive MIRNA annotations, highlighting the need for more robust validation methods. miRScore was developed as an independent and efficient tool for evaluating new...
Image credit: Pawel Czerwinski
11/07/2025
research article
Biological systems often evolve across multiple time scales, posing major challenges for constructing accurate models directly from data. Traditional model reduction techniques require explicit equations...
Image credit: Nathan Andersen
This Collection aims to increase the coverage of computational biology-related topics in Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
This series of perspective articles from computational biologists in a variety of countries, offers their personal viewpoint on the history, current status, and future of computational biology in their region.
This collection aims to provide practical tutorials and background information on important computational methods used to investigate key biological questions, as well as resources for training scientists at all stages of their careers.
The Benchmarking collection help readers decide between a number of methods which are developed to solve scientific problems.
Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform
Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys
Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data
Connect with Us