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      PLOS Neglected Tropical Diseases

January 1, 2025

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11/03/2025

Research Article

Hiss and tell: What influences venom yields of India’s big four snakes?

Snake venoms have evolved over millions of years to subdue prey and deter predators rapidly. The potency and amount of venom differ both within and across species, and are primarily influenced by their ecology and environment. Understanding venom yields in clinically relevant species is essential for refining treatment approaches for snakebite. Despite this, venom yields have seldom been documented...

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Hiss and tell: What influences venom yields of India’s big four snakes?

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11/03/2025

Research Article

Mining and malaria in the Brazilian Amazon and in the Yanomami indigenous land

Illegal mining expanded in the Brazilian Amazon since 2018, leading to increases in malaria among indigenous populations, particularly the Yanomami. We describe the temporal and spatial pattern of malaria and mining in indigenous lands and quantify the impact of mining on malaria among the Yanomami. We estimate that a 1% increase in the annual mining area was associated with a 24% (95% CrI: 17%, 32%) increase in...

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Mining and malaria in the Brazilian Amazon and in the Yanomami indigenous land

10/31/2025

Review

Translesion synthesis and microhomology-mediated end-joining repair in trypanosomatids

Trypanosomatid parasites and the diseases they cause affect more than 30 million people annually worldwide. To develop treatments for these diseases, it is critical to understand how trypanosomatid biology protects the parasite, so that these mechanisms may be exploited as drug targets. An important aspect of trypanosomatid survival is protection from oxidative damage inflicted by the host. Reactive oxygen...

Image credit: pntd.0013626

Translesion synthesis and microhomology-mediated end-joining repair in trypanosomatids

11/03/2025

Research Article

Virome profiling of Culex tarsalis through small RNA-seq: A challenge of suboptimal samples

Viral infections in mosquitoes trigger the RNA interference (RNAi) pathway, a key antiviral defense mechanism that generates virus-derived small RNAs (vsRNAs). Given the natural enrichment of vsRNAs during infection and their stability, small RNA sequencing (sRNA-seq) has emerged as a powerful tool for virome characterization. Culex tarsalis is a...

Virome profiling of Culex tarsalis through small RNA-seq: A challenge of suboptimal samples

Image credit: James Gathany, USCDCP

10/30/2025

Research Article

Hidden threats in urban environments: Angiostrongylus cantonensis in Banda Aceh’s cityscape

Angiostrongylus cantonensis is a mollusk-borne parasitic nematode originating in Southeast Asia. Commonly known as the rat lungworm, it uses rats as definitive hosts, though other mammals, including humans, can be infected and typically suffer from neurological disorders. This study focuses on the parasite’s...

Hidden threats in urban environments: Angiostrongylus cantonensis in Banda Aceh’s cityscape

Image credit: pntd.0013634

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PLOS Neglected Tropical Diseases | ISSN: 1935-2735 (online)